Nutrition and Cancer Prevention (Nutrition and Disease Prevention)

Nutrition and Cancer Prevention (Nutrition and Disease Prevention)

Language: English

Pages: 640

ISBN: 0849339456

Format: PDF / Kindle (mobi) / ePub


Epidemiological studies have estimated that approximately 35 percent of cancers are potentially avoidable by nutritional modification. These modifications include strategies such as caloric restriction and limitation of specific macro-nutrient groups. However, recent research indicates that what you eat may well be just as important as what you shun when it comes to avoiding cancer, especially colon, breast, and prostate cancers, which have become epidemic in the Western hemisphere.

Nutrition and Cancer Prevention brings together the top experts in nutritive health who present significant evidence that specific dietary micronutrients have the potential to play a role in resisting cancer, modulating its development, or reducing tumor metastasis. As a way of introduction, the book updates the descriptive epidemiology of the major cancers of the Western world, and then discusses the likely mechanisms of action that occur when certain essential nutrients become diet staples. The text moves on to explore the scientific evidence, looking at the various properties of each class of micronutrient, chapter by chapter.

These classes include vitamins; minerals, particularly calcium and selenium; phytosterols and polyphenols, which are found in soy and green tea; isothiocyanates  found in broccoli, kale, and other cruciferous vegetables; and specialized dietary lipids, including omega-3 fatty acids, linoleic acid, and sphingolipids. The book also dedicates chapters to the roles that obesity and excessive alcohol consumption play in cancer development.

“…we can hope to utilize nutritional interventions to slow the progression of tumor development in the intraepithelial hyperplasia phase before tumor size becomes large enough for diagnosis and probability of metastasis increases. Opportunity exists to stretch this prevention phase so that symptom-free life of the future patient with cancer is prolonged.”

--from  Chapter 2, How Dietary Components Protect from Cancer, Diane M. Harris and Vay Liang W. Go

 (Possible illustration

TABLE 2.1

Partial List of Bioactive Food Components with Cancer-Preventive

Properties That Are Detailed in This Volume and Their Primary Food

Sources

Chapter two)

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Senescence................................................................42 2.5.5 Inhibition of Angiogenesis ............................................................43 2.5.6 Inhibition of Tissue Invasion and Metastasis................................43 2.5.7 Increased Antioxidant Capacity and Genomic Stability...............44 2.5.8 Other Mechanisms.........................................................................45 2.5.8.1 Inflammation

Detailed in This Volume and Their Primary Food Sources Class Example Bioactive Compounds Isothiocyanates Phenethyl isothiocyanate Sulforaphane Saponins Curcuminoids Fatty Acids Omega-3 fatty acids Conjugated linoleic acids Sphingolipids Sapogenin, ginsenoside Curcumin Eicosapentaenoic acid, docosahexaenoic acid cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid Ceramide, sphingomyelin Dietary Source Watercress Broccoli and other cruciferous vegetables Legumes, soybean, ginseng

metastases than homozygous (BB) women. Similarly, a recent study by Buyru et al.51 has further shown that the prevalence of both the VDR Taq I and Bsm I alleles and the genotype frequencies were similar in both the normal population and patients with breast cancer. 98 Nutrition and Cancer Prevention Because endogenous hormone exposure is known to alter breast cancer susceptibility, genetic variations in VDR along with another nuclear hormone receptor, the androgen receptor (AR), were

testosterone compared to the placebo group.21 This finding has been regarded as a possible explanation of the selective reduction in prostate cancer observed in the ATBC Country Finland No. of Subjects 29,133 Type of Study Type of Cancer Cohort Prostate China USA USA 29,584 21,116 24-county Intervention Case-control Case-control Lung Stomach, pancreas, colorectal Stomach Prostate Breast USA USA 1,045 923 33-county Cohort Case-control Stomach Colon Netherlands USA USA 58,279

studies on marrow cells in B12 and folate deficiency. Blood 1966; 28:581–594. 29. Das KC, Mohanty D, Garewal G. Cytogenetics in nutritional megaloblastic anaemia: prolonged persistence of chromosomal abnormalities in lymphocytes after remission. Acta Haematol 1986; 76:146–154. 30. Libbus BL, Borman LS, Ventrone CH, Branda RF. Nutritional folate-deficiency in Chinese hamster ovary cells. Chromosomal abnormalities associated with perturbations in nucleic acid precursors. Cancer Genet Cytogenet

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