Mims' Medical Microbiology
Language: English
Pages: 580
ISBN: 0808924400
Format: PDF / Kindle (mobi) / ePub
Mims’ Microbiology makes it easy for you to learn the microbiology and basic immunology concepts you need to know for your courses and USMLE. Using a clinically relevant, systems-based approach, this popular medical textbook accessibly explains the microbiology of the agents that cause diseases and the diseases that affect individual organ systems. With lavish illustrations and straightforward, accessible explanations, Mims’ Microbiology makes this complex subject simple to understand and remember.
- Learn about infections in the context of major body systems
- Grasp and retain vital concepts easily
- Effectively review for problem-based courses
- Approach microbiology by body system or by pathogen
- Access the complete contents online at studentconsult.com
and understand why these are environments in which microbes can establish themselves, flourish, and give rise to pathologic changes. This systems-based approach to microbiology employs integrated and case-based teaching that places the "bug parade" into a clinical context.
thanks to a user-friendly color-coded format, succinct text, key concept boxes, and dynamic illustrations.
with the help of chapter introductions and "Lessons in Microbiology" text boxes that highlight the clinical relevance of the material, offer easy access to key concepts, and provide valuable review tools.
through an extensively cross-referenced "Pathogen Review" section.
, along with downloadable illustrations…150 multiple choice review questions... "Pathogen Parade"...and many other features to enhance learning and retention.
- Enhance your learning and absorb complex information
- Deepen your understanding of epidemiology and the important role it plays in providing evidence-based identification of key risk factors for disease and targets for preventive medicine.
in an interactive, dynamic way with Pathogen Parade – a quickly searchable online glossary of viruses, bacteria, and fungi.
A completely re-written chapter on this topic keeps abreast of the very latest findings.
this point of view (e.g. meningococcal meningitis, paralytic poliomyelitis). infection skin, throat, lung, intestine, etc. surface infection failure to spread to deeper tissues (e.g. influenza virus in respiratory epithelium*) + deeper tissues * the same principle applies to gut or vascular endothelium Figure 15.2 Topography of virus release from epithelial surfaces can determine the pattern of infection. 154 * blood vessel + + sites of possible multiplication multiplication in
longer and secondary responses have more opportunity to come into action and control an infection by an antigenic variant. Accordingly, antigenic variation is not an important feature of these systemic infections. At the molecular level, there are three main mechanisms for antigenic variation: Figure 16.8 Antigenic variation as a microbial strategy. The change in antigens may take place in the originally infected individual, enabling the microbe to undergo renewed growth (e.g. trypanosomiasis,
PrPSc exists as a free globular glycoprotein, which can interact with PrPc. (3) PrPc is released from the cell membrane and is converted into PrPSc. (4) Cells produce more PrPc and the cycle is repeated. (5) PrPSc accumulates as plaques, and is internalized by cells. The development of scrapie in sheep shows strong genetic influences, some breeds being much more resistant than others, and similar genetic effects have been shown in mice. In humans, homozygosity for methionine at codon 129 of the
protease creates large numbers of the C4b2a convertase which itself also having proteolytic activity, cleaves many C3 molecules, this so-called enzyme cascade providing a mechanism for the striking amplification of the relatively few initial complement activation events. C4b2a has a similar function to the alternative pathway C3 convertase, C3bBb , and the sequence of events following the splitting of C3 which generates an acute inflammatory response is indistinguishable from that occurring in
Organisms that are small enough can live inside cells and, by doing so, establish a biologic relationship with the host that is quite different from that of an extracellular organism – one that influences both disease and control. LIVING INSIDE OR OUTSIDE CELLS The basis of all host–pathogen relationships is the exploitation by one organism (the pathogen) of the environment provided by another (the host). The nature and degree of exploitation varies from relationship to relationship, but the